The grille designs remained the same as the previous S50-2 models, with the S50D-3 Deluxe model using a cast alloy grille with one wide horizontal bar at 3/4 height with 4 thin horizontal bars above it and 12 thin horizontaal bars below. The standard models used the same pressed steel grille that had been used since the first S50S-1 model. The Estate model continued in production, but only as a standard model, with roughly the same equipment and trim as the standard sedan. It also used the standard grille. The commercial vehicle van version available in the previous models has been dropped from the range.

The car continued to use the ever faithful 1484cc OHV G-1 engine, though this would be the last car to do so. By this stage Prince had a new engine design ready that was intended to be used in the next generation Skyline, the C10 series, so they decided to fit this engine to a range topping version of the S50D-3 that would be designated the S57D. This new engine was called the G-15, and it was a quantum leap in engine design for Prince. The engine was by far the most technologically advanced Japanese passenger car engine in it's day, eclipsing even Nissan's Yamaha-designed L series engines in their design. The engine was a 1483cc single overhead cam engine with a cross-flow alloy cylinder head. It had a V shaped valve arrangement and a multi-spherical combustion chamber design and a 5 main bearing crankshaft. The engine produced 94hp, or 88ps, as the Japanese like to measure it. The S57D had only two external features that differentiated it from the S50D-3, which was an 88 badge in the grille (it's power measured in Pferdestärken), and a discrete OHC badge above the reversing light on the right hand side.

Initially the cars were sold with badges that said "Prince" on the boot lid and "Skyline 1500" on the side of the car. They also had a small rectangular "NISSAN" badge on the left side of the grille and the same "NISSAN" badge mounted above the left side reversing light at the back. Deluxe models said "Skyline 1500 Deluxe" on the sides. Soon the Prince name was dropped altogether. After that the cars had a "NISSAN" badge in the same style as the old Prince badge on the boot lid, and the small rectangular "NISSAN" badge above the reversing light disappeared. They continued to use the "NISSAN" badge on the grille, but on the side of the car it said either "NISSAN SKYLINE Deluxe" or "NISSAN SKYLINE". It still kept the stylised P emblem on the bonnet.

The last of these cars was built in September 1968, and it was replaced with the all new C10 series Skyline in October 1968. The new C10 series would use the new G-15 engine, as well as the enlarged G-18 and G-20 versions of the engine. The G-15/18/20 engines would prove to be not economically viable to adapt to the ever tightening US emissions standards, whereas the Nissan L series was. Thanks to this issue the engine was taken out of production in the early to mid 1970s, and from then on all Prince designed Nissans used Nissan engines. The Skyline name has now been in continuous use for well over half a century, one of only a handful of vehicle names to do so.